Morrie Schwartz: Morrie is Mitch’s former college professor who has been diagnosed with ALS (Lou Gherig's disease). He meets with Mitch in his home every Tuesday and teaches him about the meaning of life.

Mitch Albom: Morrie's former student who has since become a journalist with a very busy life. After sixteen years of being out of touch, he sees Morrie on ABC's Nightline and starts to visit him every Tuesday.